ABSTRACT
Etoricoxib, a non-steroidal anti-inflammatory drug, is used to Osteoarthritis, Rheumatoid arthritis and Acute Gouty arthritis. Etoricoxib is practically insoluble in water; hence present study was carried out to enhance dissolution properties of Etoricoxib through the preparation of Solid Dispersions using PEG 6000 as carrier at various proportions by using different techniques like Physical mixtures, Kneading Method and Solvent Evaporation Method. The drug release profile was studied in 0.1N HCl containing 1 % SLS. U.V. Spectrophotometric method was selected for assay as well as in-vitro dissolution studies at 234nm.All the solid dispersions exhibited superior dissolution than pure drug. The drug dissolution studies followed first order kinetics. Solvent evaporation method was found to be superior to other methods.
ABSTRACT
Two simple and sensitive visible spectrophotometric methods (A & B) for the determination of Lornoxicam (LOC) in bulk and pharmaceutical dosage forms are described. Method A is based on oxidation of drug with Ferric Chloride and subsequent complexation of Fe(II) with 2, 2' Bipyridine to form a blood red colored species ( λmax :520 nm). Method B is based on oxidation of LOC with Ferric Chloride and chelation of Fe (II) with Bathophenanthroline to produce a blue colored chromogen (λmax: 610 nm). These methods were extended to the analysis of pharmaceutical formulations and results compared with the reference method.
ABSTRACT
Two simple and sensitive spectrophotometric methods have been developed for the estimation of Nebivolol hydrochloride in pure and pharmaceutical dosage forms. Method 1 is based on Ion-association complex formation of the drug with (SBT λmax 515 nm). Method 2 is based on Ion-association complex formation of the drug reacts with (BTB λmax 410nm). These methods have been statistically evaluated and found to be precise and accurate.